Males:
"In extreme cases, a hard strike to the testicles can cause the victim to vomit or black out and can cause the testicle to rupture, potentially sterilizing or killing the victim. There is also the possibility of shock. In many parts of the world, an attack on the male groin is considered to be sexual assault."
Females:
In extreme cases, the female victim may vomit or black out. A strike to a female's genitals can be just as damaging and debilitating as a blow to a male, if not even more so due to the location of the pubic bone just inside the female's body and the higher amount and concentration of nerve endings in the vulva than the testicles. If delivered with enough force, a kick to the female genitalia can drive the highly sensitive clitoris up into the pubic bone, compressing the clitoris between the hard bone and the attacker's shoe. Potential long-term health problems can arise for female targets of groin attacks including nerve damage to the clitoris, the pubic bone fracture because women's bones are thinner (and the bone of the pelvis of women is thinner and may break off female pelvis), hematoma, and vulvodynia.
Thank you, Wikipedia.