No.
Well the only drawback is, the remaster from TNG vanilla to TNG bluray is an all digital process.
They shot most of the thing on crummy equipment with bad black level/ sensitivity.
So, overall, when they did the remaster, they went , fk-it , and just dropped the black-levels which introduced alot of crushed details.
It looks more vivid in color, but details were lost..
So, in this scenario, the Original vanilla -has an advantage if we're talking detail-..
Although I still personally prefer the remaster..