Hi there,
I once tried the Orthomouse because it looked fantastic.
After about one week, I chose to send it back.
I really wanted to like it, but I had some gripes.
The biggest problem was my pinky.
There is not enough space to put the pinky, so you have two options:
keep it on the mouse or put it on the table.
The problem is that the mouse shape restricted where my pinky could rest.
Basically there was too much material to let my pinky just rest on the table comfortably
and too few material to actually let my pinky rest on the mouse itself comfortably.
So I could either force myself to keep the pinky on the mouse or
try to rest it on the table in an awkward angle.
I tried both.
But no matter how I tried it, after only 1 or 2 hours of use I would get bone pain in my pinky.
Another gripe I had are the different shape adapters.
The upper adapters only changed the looks for me, so I thought they are useless.
In the pictures you can see that I'm not even touching them.
Basically the only useful adapters are the prolongers.
The longest was not long enough to support my wrist fully.
So only a small part of my wrist could rest on it, making movement very awkward.
The middle one was okay, it left my whole wrist on the table.
The small one was too small.
I really liked the thumb scrolling buttons, the placement was really perfect (see pic)
and using them was a delight. I missed them a lot afterwards.
Iirc the mouse buttons were okay too.
The pinky was a no-go for me though, I could really feel that this was not healthy.
So basically I would recommend trying it out.
I have quite long hands, which often creates problems with holding mouses comfortably for me.
Maybe it's just right for you!