I like both, even if I am quite new to Iso. I definitely prefer the spacebar row in Iso, yet I prefer a little the enter and shift keys on ANSI.
They are both good for me, more so if you can remap your keys!
Edit: the Iso layout I talk about is the one on my F122, so the spacebar row is 1.5,empty 1x, 1.5,7x,1.5,1x empty,1.5 (I assume the 7x, but not 100% sure)