I assume the problem with copypasta and similar chords are contorted fingers, when pressing Ctrl with left pinkie and ZXCV with ring/middle/index finger.
(a) Use sticky keys. Then you can press Ctrl and then the other key from the combo, without contorting fingers to strike a chord.
(b) Use the right Ctrl key with the other hand (on the other side of the keyboard).
(c) Those chords originated on MacOS as Cmd-[ZXCV]. Cmd is pressed with a thumb on mac keyboards. If you have a keyboard with more or wider modifiers, you can remap the innermost (closer to the spacebar) to Ctrl.
(c} If you haven't remapped Caps Lock to anything more useful, make it a special Fn-like modifier, that activates a custom layer. You can put macros or even utilize dedicated "multimedia" codes (that include copy/paste/undo/…) there.
(d) Similarly, you can remap keys, that you don't use otherwise, e.g., numpad, function keys etc.
(e) Use alternative approaches to desired functions. This may involve using the pointing device or other software with an entirely different user interface (e.g., Vim instead of Notepad clones, VimFx/Vimperator in web browser, some keyboard-oriented file manager with vi-like or original CUA controls).
In case of gaming on WASD or something similar, switch to an entirely different control scheme. It might appear counterintuitive at first sight, but take a look at controls used by old-school Quake players. Or, as I've mentioned, you can rotate the keyboard so that your thumb rests on Ctrl/Shift and fingers are aligned on 2EDX or something—that way, you're not stuck on straight rows.