you have to setup a gaming layer, depending on how seriously you play the game.
for example
the space key on the EDx is on the Right,
For games that don't allow you to remap, you need to put it back on the LEFT.
And depending on the size of your hand, you might make the right most 1x on the non-thumb cluster section ALSO a space key
This is for comfort, so you don't have to move your wrist at all
Alternatively,
You could switch the keys one step over and use the regular space key which would normally be back space, but is not customed for space
The point is, The flexibility is there on the ergodox.. all things are possible..