Evoluent is by far the best shape..
I can understand how a novice to ergonomics might not understand how to use one. .hahahaha
Very basically, you have to learn to lightly pinch the mouse between the thumb and pinky..
Ontop of that, Mouse height must be adjusted to BELOW elbow height..
There is an adjustment in TECHNIQUE, that comes with vertical mousing..
You can't expect all your old habits to work, they don't..
Fohat's complaint is the same as those who are not using the ERGODOX properly
As for 45* mouse, It does not solve the wrist angle problem whatsoever
The reason is, If you tilt even 45degrees, you are STILL rotating inwards in order to click the button..
You're essentially pushing against the rotation in your wrist..
This rotational stress is responsible for the majority of forearm related RSI..
I think , the next step, even better, is something similar to the FPS gun mouse by Zalman..