I wipe my mouse with isopropyl alcohol, wet naps, and/or a soap and water. Mouse pad gets hand washed in the tub/sink with a bit of laundry detergent and soap. Add water, soap, and detergent, roll the mouse pad up and scrub. Or you can use a cloth. I just air dry when I'm done. I've done this to all my mice with no issue. And I have the smaller Steelcase QCK+ mousepads.