It depends on your gaming layout (I'm assuming you're asking for gaming and not necessarily traditional touch typing): for traditional WASD layout, and when in a movement heavy situation, I normally leave the tip of my pinky on the keyboard chassis leaning against the upper edge of the shift key, I'd say I have normal-ish size (male) hands so I can easily access 1 2 3 4 Q E R F Z X C along with the W A S D cluster from this position; some times, when I shift from heavy movement to heavy ability usage, I slide my pinky up to the bottom corner of the tab key, so that the number row is more accessible. I don't leave my pinky on the chassis the whole time, just when I need to quickly gain my bearings after fishing for lesser used key binds (6+, T, G, V).
I've also removed my caps lock key-cap, it just seemed to get in the way and I didn't want to bust out the dremmel to mutilate the thing, lol. If I were to go even further I'd probably add tactile dimples to a few keys (mainly V for thumb use and 4 7/8 to make quick passes over the number row more easily), but I haven't found it really necessary, haha.
edit; the point I'm trying to get across is to find or make "landmarks" since you probably won't have access to the ones normally provided by the F and J keys while gaming.