Suppose you type 75 words per minute constantly for 8 hours per day. I think an average word in English is about 5.3 characters. And further, let's assume that the most frequently pressed key gets hit about 1/5th of the time.
So the most common key gets pressed 75*5.3*60*8/5 = 38160 time per day. Taking 50,000,000 divided by this gives a little over 1310 days, or just under 3.6 years.
So, if your job consisted of pressing a key 75 times per minute for 8 hours straight per day, every day of the year, you'd wear that key out in about 3.6 years.
I just checked and the letter 'e', being most common in English is about 12.7% of all letters typed.
Also, at this rate, you'd be writing a 100,000 word novel in just under 2.8 days of work.
Anyway, for all practical purposes a long long time.