I've determined that I'm almost entirely alone in this, but my office is my livingroom. I two-screen it, with a computer monitor next to me, and the big screen TV at the head of the room. That being said, my setup is a recliner. Keyboard on my lap, mouse on the right arm of the recliner, nostromo on the left for gaming. It's an oustanding setup, and is extremely comfortable. The only problem I face is when I play a game while I have a movie up on the big screen. End up getting a pain in my next from turning my head to the side for hours on end looking at my monitor.
That being said, keyboard on my lap, I find it gives me a very satisfying sound on my blues.