Kinesis, you order online, pay and get in couple of days.
Ergodox, you wait for group buy (days, weeks, months), you send your money (more or less same as Kinesis), you wait for group buy to finish (weeks), then you wait for part to arrive (weeks, months), then you build it yourself (hours).
As for layout, can't say as I don't have either (yet), but Ergodox has more usable keys, they're all mechanical and it's fully split, but the halves are all flat, while on Kinesis it's nicely contoured which seems very ergonomic.