Well, you can overdo anything and hurt yourself if you go at it intensely enough. However… If I may speculate, I would guess that VR gaming will be less prone to RSI, because the movements are more varied and engage more of the body rather than just twitching the same few little muscles over and over. I laugh a little at "E-sports", but to me playing in VR feels a bit closer to real sports when I'm ducking, dodging, punching, etc. Some of the games can be a fair aerobic workout.