I haven't used the Ducky Zero so I'm kind of talking out of my ass, but my experience with keyboard Mac compatibility is that nearly all USB keyboards will work just fine on a Mac. Sometimes media/extra keys won't work, and of course the command/option keys position will be swapped, but everything else will work just fine. Some boards use tricks to achieve NKRO and these usually do NOT work on Macs, but it can be turned off on this Ducky so it shouldn't be a problem.