Wear and Tear, on hardware is not trivial, especially now that alot of computer hardware fall into the -Budget- electronics category.
It's Mainly the Power circuits, they're not designed for 24 hr operation, the vrms are almost always stretched.
It may or may not be the gpu's fault, the mobo could be delivering bad current, or maybe there's a leak/ short somewhere.
Point is, NEVER run folding at home, unless you got the more expensive parts which use more and better regulators.