i use a tented ergodox at work, and an ansi 60% at home. the reasoning being that i'm typing and such at work for like hours a day, so it's important to be ergonomic. i use an ansi board at home because while i still type text, i'm extremely used to the layout for gaming. anything else feels bizarre.
i had the same concern as you before i bought the ergodox, but 4 months on, i realise that the layout of the ergodox is so different to a regular layout, that my hands almost treat them as two separate methods of inputting text.
ironically, i found that i hated DSA profile caps so much on my ergodox that i didn't feel comfortable on it until i got a set of cherry profile caps for it